Archive for July, 2008

Excelent - Viktor Meyer

Thursday, July 31st, 2008

Viktor Meyer (8 September, 1848 – 8 August, 1897) was a German chemist and significant contributor to both organic and inorganic chemistry. He is best known for inventing an apparatus for determining vapour densities, the Viktor Meyer apparatus, and for discovering thiophene, a heterocyclic compound. He is sometimes referred to as Victor Meyer, a name used in some of his publications.

Contents


Life

Viktor Meyer was born in Berlin (1848) as the son of trader and cotton printer Jacques Meyer and Bertha Meyer. His parents were Jewish, though he was not actively raised in the Jewish faith. Later, he was confirmed by the reformed Jewish Church. He married a Christian woman (Hedwig Davidson) and raised his children as such. He entered the gymnasium at the age of ten at the same class as his two year older brother Richard. Although he had excelent science skills his wish to become an actor was based on the love for poetry. At a visit of his brother Ricard, who was studying chemistry at the University of Heidelberg, he became atracted to chemisty.

In 1865, when not even 17 years old but pushed by his parents, Meyer began studying chemistry at the University of Berlin, the same year that August Wilhelm von Hofmann succeeded Eilhard Mitscherlich as the chair of chemistry there. After one semester, Meyer went to Heidelberg to work under Robert Bunsen, there also hearing lectures on organic chemistry by Emil Erlenmeyer. As no research was required under Bunsen at the time, Meyer received his doctorate in 1867, at the age of nineteen. This opened the doors to a very successful career in which he became one of the most important chemists of his time. He stayed one year with Bunsen for an area wide analysis of spring water. Besides this he was also able to teach some PhD students. He joined the group of Adolf Baeyer, one of his best friends in later life, in Berlin changing from inorganic chemistry to organic chemistry. At the age of 23 Baeyer sent him to Stuttgart at a request from Fehling for a student capable to be a lecturer at the University.

Overworked and overtaxed, Meyer’s nervous system suffered, leading to several minor and major nervous breakdowns during the last years of his life. He always failed to recover completely, yet continued working. He took pills to fall asleep, but these had a damaging effect on his nervous system. In one of his depressions, Meyer decided to take his own life, and committed suicide by taking cyanide. He died at the age of forty-nine during the night of August 7 - August 8 1897 in Heidelberg. It was a shock to others as Meyer was considered a highly gifted scientist by his colleagues, and a very talented teacher by his students.


Career

Meyer’s professional career:

1867 Assistant at the laboratory of Robert Bunsen, analyzing mineral water for the government of Baden and helping students preparing their examinations
1868 Studying organic chemistry at the Gewerbe-Akademie in Berlin, guided by Adolf von Baeyer (until 1871)
1871 Position as Professor extraordinarius of organic chemistry at the Polytechnikum of Stuttgart, allowed without habilitation
1872 Position as Professor ordinarius at the Polytechnikum of Zurich
1885 Position at the University of Göttingen, occupying the famous Chair of Friedrich Wöhler
1889 Taking over the Chair of Robert Bunsen at the University of Heidelberg; Meyer was requested (by Bunsen) to take this position in 1888, but only complied after a second request in 1889

Scientific contributions:

  • Synthesis of aromatic carboxylic acids from sulfonic acid and formiates (1869).
  • Nitroalkanes from alkyl iodides and silver nitrite (1872).
  • Development of a method to distinguish primary, secondary and tertiary nitroalkanes (1875).
  • Starting with studying physical chemistry in 1876, Meyer created a new method for determining gas density in 1878. This method allowed him to demonstrate how arsenious oxide vapours corresponded to the formula As4O6, that mercury, zinc and cadmium yielded monatomic vapours, and that halogen molecules dissociated into atoms on heating, a phenomenon which he studied until his death. The Victor Meyer apparatus accurately measures the volume of a volatilized substance from which the vapor density of the gas can be derived and also the relative mass.
  • Proposing glucose is an aldehyde and not a ketone, hereby correcting von Baeyer and van’t Hoff (1880).
  • Synthesis of aldoximes and ketoximes from hydroxylamine and aldehydes or ketones, hereby discovering a new structural identification and elucidation method (1882, together with Alois Janny).
  • Identification of thiophene as a contaminant in benzene derived from coal (1882). Benzene produced by decarboxylation of benzoic acid did not contain this impurity.
  • First reliable synthesis of pure sulfur mustard (1886, also see Meyer’s account on sulfur mustard)
  • Coining of the concepts of stereochemistry and dipole in 1888. Meyer had always been interested in stereochemical problems and was one of the first ones to instruct his pupils with van’t Hoff’s theory of asymmetric carbon and the Hantzsch-Werner theory.
  • Discovery of iodoso compounds in 1892 by reacting o-iodobenzoic acid with nitric acid.
  • Observation (1892) that ortho-substituted benzoic acid derivatives are esterified with difficulty. This principle is now known as the Victor Meyer esterification law and was discovered in an attempt to esterify o-iodosobenzoic acid.
  • Discovery of iodonium compounds by reacting iodobenzene and iodosobenzene (1894).

Books:

Meyer wrote several notable books:

  • Tabellen zur qualitativen Analyse (1884, written together with Frederick Treadwell)
  • Pyrochemische Untersuchungen (1885)
  • Die Thiophengruppe (1888)
  • Chemische Probleme der Gegenwart (1890)
  • Ergebnisse und Ziele der Stereochemischen Forschung (1890)
  • Lehrbuch der organischen Chemie (1893, written together with Paul Jacobson. A very popular book at the time that has been reprinted and reedited several times)
  • Märztage im kanarischen Archipel, ein Ferienausflug nach Teneriffa und Las Palmas (1893, travel guide)


See also

  • Victor Meyer apparatus: In a demonstration in Cohen’s Practical Organic Chemistry (1910) the molar mass of diethyl ether was determined experimentally at 72 g/mol and that for aniline 93 g/mol.


Further reading

  • Richard Meyer. Victor Meyer. Leben und Wirken eines deutschen Chemikers und Naturforschers,1848-1897 (Akademische Verlagsgesellschaft, 1917) (note: Richard Meyer is Victor Meyer’s brother).


References

  • W Pötsch. Lexikon bedeutender Chemiker (VEB Bibliographisches Institut Leipzig, 1989) ISBN 3-8171-1055-3)
  • E von Lippmann. Zeittafeln zur Geschichte der organischen Chemie (Julius Springer, 1921)
  • G Bugge. Das Buch der grossen Chemiker (Verlag Chemie GmbH, 1955)

Juvenile diabetes is considered - Juvenile and Domestic Relations District Court

Wednesday, July 30th, 2008

A Juvenile and Domestic Relations District Court, in Virginia, handles all cases involving juvenile crime, child abuse or child neglect, disputes involving custody and visitation, and other family-related matters, as well as cases in which a child or family member is an alleged victim (it can try misdemeanors, but only preliminary hearings in adult felonies). A judge hears all cases. Appeals from J&DR court go to Circuit Court.

The court also has authority to allow minors, under certain circumstances, to seek abortions. It may also emancipate a child.


References

The Juvenile and Domestic Relations District Court.

Research - National Institute for Research Advancement

Tuesday, July 29th, 2008

The National Institute for Research Advancement (NIRA) is a Japanese independent policy research body based in Tokyo founded in 1974 under the National Institute for Research Advancement Act. It is funded through an endowment comprising capital contributions and donations from public and private sectors.

Its objective is to conduct independent research to contribute to the resolution of contemporary complex social issues in many areas, including politics, economics, international affairs, society, new technologies, and administration.

It maintains a World Directory of Think Tanks.


See also

  • Home page

How diabetes - Steroid diabetes

Monday, July 28th, 2008

Steroid diabetes is a medical term referring to prolonged hyperglycemia due to glucocorticoid therapy for another medical condition. It is usually, but not always, a transient condition.

The most common glucocorticoids which cause steroid diabetes are prednisone and dexamethasone given systemically in “pharmacologic doses” for days or weeks. Typical medical conditions in which steroid diabetes arises during high-dose glucocorticoid treatment include severe asthma, organ transplantation, cystic fibrosis, inflammatory bowel disease, and induction chemotherapy for leukemia or other cancers.

Glucocorticoids oppose insulin action and stimulate gluconeogenesis, especially in the liver, resulting in a net increase in hepatic glucose output. Most people can produce enough extra insulin to compensate for this effect and maintain normal glucose levels, but those who cannot develop steroid diabetes.

The diagnostic criteria for steroid diabetes are those of diabetes (fasting glucoses persistently above 125 mg/dl (7 mM) or random levels above 200 mg/dl (11 mM)) occurring in the context of high-dose glucocorticoid therapy. Insulin levels are usually detectable, and sometimes elevated, but inadequate to control the glucose. In extreme cases the hyperglycemia may be severe enough to cause nonketotic hyperosmolar coma.

Treatment depends on the severity of the hyperglycemia and the estimated duration of the steroid treatment. Mild hyperglycemia in an immunocompetent patient may not require treatment if the steroids will be discontinued in a week or two. Moderate hyperglycemia carries an increased risk of infection, especially fungal, and especially in people with other risk factors such as immunocompromise or central intravenous lines. Insulin is the most common treatment.

Steroid diabetes must be distinguished from stress hyperglycemia, hyperglyemia due to excessive intravenous glucose, or new-onset diabetes of another type. Because it is not unusual for steroid treatment to precipitate type 1 or type 2 diabetes in a person who is already in the process of developing it, it is not always possible to determine whether apparent steroid diabetes will be permanent or will go away when the steroids are finished. More commonly undiagnosed cases of type 2 diabetes are brought to clinical attention with corticosteroid treatment because subclinical hyperglycemia worsens and becomes symptomatic. Generally, steroid diabetes without preexisting type 2 diabetes will resolve upon termination of corticosteroid administration.

Steroid diabetes does not occur with other steroid hormones, such as anabolic steroids, mineralocorticoid, or sex steroids because these other categories of steroids have little effect on glucose metabolism.

REDIRECT: Diabetes mellitus - Hyperinsulinism

Wednesday, July 23rd, 2008

Hyperinsulinism or hyperinsulinemia refers to an above normal level of insulin in the blood of a person or animal. Normal insulin secretion and blood levels are closely related to the level of glucose in the blood, so that a given level of insulin can be normal for one blood glucose level but low or high for another. Hyperinsulinism can be associated with several types of medical problems, which can be roughly divided into two broad categories: those tending toward reduced sensitivity to insulin and high blood glucose levels (hyperglycemia), and those tending toward excessive insulin secretion and low glucose levels (hypoglycemia).

Contents


Hyperinsulinism due to diminished sensitivity, associated with diabetes risk

Although many factors influence insulin secretion, the most important control is the amount of glucose moving from the blood into the beta cells of the pancreas. In healthy people, even small rises in blood glucose result in increased insulin secretion. As long as the pancreatic beta cells are able to sense the glucose level and produce insulin, the amount of insulin secreted is usually the amount required to maintain a fasting blood glucose between 70 and 100 mg/dL (3.9-5.6 mmol/L) and a non-fasting glucose level below 140 mg/dL (<7.8 mmol/L).

When liver cells and others that remove glucose from the blood become less sensitive and more resistant to the insulin, the pancreas increases secretion and the level of insulin in the blood rises. This increased secretion can compensate for reduced sensitivity for many years, with maintenance of normal glucose levels. However, if insulin resistance worsens or insulin secretion ability declines, the glucose levels will begin to rise. Persistent elevation of glucose levels is termed diabetes mellitus.

Typical fasting insulin levels found in this type of hyperinsulinism are above 20 μU/mL. When resistance is severe, levels can exceed 100 μU/mL.

In addition to being a risk factor for type 2 diabetes, hyperinsulinism due to insulin resistance may increase blood pressure and contribute to hypertension by direct action on vascular endothelial cells (the cells lining blood vessels). Hyperinsulinism has also been implicated as a contributing factor in the excessive production of androgens in polycystic ovary syndrome.

The principal treatments of hyperinsulinism due to insulin resistance are measures that improve insulin sensitivity, such as weight loss, physical exercise, and drugs such as thiazolidinediones or metformin.


Hyperinsulinism due to inappropriate secretion, associated with hypoglycemia

Hyperinsulinism is also used in medical contexts to refer to forms of hypoglycemia caused by excessive insulin secretion. In normal children and adults, insulin secretion should be minimal when blood glucose levels fall below 70 mg/dL (3.9 mM). There are many forms of hyperinsulinemic hypoglycemia caused by various types of insulin excess. Some of those that occur in infants and young children are termed congenital hyperinsulinism. In adults, severe hyperinsulinemic hypoglycemia is often due to an insulinoma, an insulin-secreting tumor of the pancreas.

Insulin levels above 3 μU/mL are inappropriate when the glucose level is below 50 mg/dL (2.8 mM), and may indicate hyperinsulinism as the cause of the hypoglycemia. The treatment of this form of hyperinsulinism depends on the cause and the severity of the hyperinsulinism, and may include surgical removal of the source of insulin, or a drug such as diazoxide or octreotide that reduces insulin secretion.

Dr. Seale Harris first diagnosed hyperinsulinism in 1924 and also is credited with the recognition of spontaneous hypoglycemia.


Hyperinsulinism due to insulin injection

The treatment of diabetes mellitus with insulin replacement therapy can easily result in diabetic hypoglycemia due to the difficulty of balancing insulin delivery.

Transient hyperinsulinism can also occur when insulin is injected by non-diabetic athletes attempting to enhance their anaerobic performance.


References

Juvenile diabetes mellitus and - OneTouch Ultra

Friday, July 18th, 2008

OneTouch Ultra is a blood glucose monitoring device for people with diabetes and is the foundation product for LifeScan’s OneTouch Ultra Family of blood glucose monitoring systems.

OneTouch Ultra Blood Glucose Meters provide blood glucose test results in 5 seconds, offer alternate test site options, and various memory and flagging features.

OneTouch Meters are sold in kits containing a carry case, a lancing device, control solution, sample quantities of lancets, and a replacement cap for use with the sampling device when using alternate site testing.

The OneTouch Ultra 2 is similar in design and operation to the OneTouch Ultra Meter, but also offers Before and After Meal Flags, Comments, and a list style memory recall. This meter also provides 7 day, 14 day, and 30-day averages, with the option of averaging Before meal or After Meal records.

Other OneTouch Ultra Meters include the OneTouch UltraSmart and the OneTouch UltraMini Meter (known as the OneTouch UltraEasy in Europe). In addition to the original Silver Moon color, LifeScan introduced three additional colors of the OneTouch UltraMini Meter in summer 2007: Pink Glow, Limelight, and Jet Black.

OneTouch Meters with data ports can be used in combination with the downloadable OneTouch Diabetes Management Software and a PC to compute averages and trends. The software is available from LifeScan’s Web site but an interface cable must be purchased.


Notable ad campaigns

  • B.B. King has had diabetes for 10+ years. He was in an ad campaign for OneTouch Ultra, describing how blue he feels from diabetes. There was also a commercial with him and a younger person with diabetes who also played blues music. The campaign promoted the use of alternate site testing.
  • Patti Labelle has had diabetes for 12+ years. She was in an ad campaign for OneTouch Ultra2, describing how she collapsed on stage and discovered she had diabetes. Labelle re-recorded her 80’s hit New Attitude (Patti Labelle song) for one of the commercials.
  • OneTouch is also the main shirt sponsor of Inverness Caledonian Thistle, highlighting LifeScan’s presence as a major employer in the city.


See also

  • LifeScan
  • Animas Corporation


References

  • OneTouch Meters
  • OneTouch UltraMini Meter
  • OneTouch Ultra2 Meter
  • OneTouch Ultra Meter

As type 2 diabetes - Mother Love

Thursday, July 17th, 2008

Mother Love is an American entertainer. From 1998 to 2000, she was the original host of Forgive or Forget. In addition, she has hosted on radio in Los Angeles radio stations KLSX, KACE FM, and a show on KFI. She came from Cleveland OH radio. She also appeared in such movies as Volcano , Mr. Nanny and 11 other films. She has also done many TV programs.

Mother Love is the author of Listen Up Girlfriends, Forgive or Forget, Never Underestimate the Power of Forgivenessand her latest book, “Half the MOTHER twice the LOVE, My Journey to Better Health with Diabetes” (Oct.2006). She is a correspondent for dLife TV, She is an active volunteer with the American Diabetes Association for many years, she is a spokesperson for the ADA’s new I Decide to FIGHT Diabetes Campaign and travels the country promoting Diabetes Awareness. She is a motivational speaker on many family and womens issues. Mother Love is a member of Sigma Gamma Rho, one of four sororites in the National Pan-Hellenic Council.


External links

  • Official website

Site for - Cross-site cooking

Thursday, July 17th, 2008

Cross-site cooking is a type of browser exploit which allows a site attacker to set a cookie for a browser into the cookie domain of another site server.

Cross-site cooking can be used to perform session fixation attacks, as a malicious site can fixate the session identifier cookie of another site.

Other attack scenarios may also possible, for example: attacker may know of a security vulnerability in server, which is exploitable using a cookie. But if this security vulnerability requires e.g. an administrator password which attacker does not know, cross-site cooking could be used to fool innocent users to unintentionally perform the attack.

Cross site. Cross-site cooking is similar in concept to cross-site scripting, cross-site request forgery, cross-site tracing, cross-zone scripting etc., in which that it involves the ability to move data or code between different web sites (or in some cases, between e-mail / instant messages and sites). These problems are linked to the fact that a web browser is a shared platform for different information / applications / sites. Only logical security boundaries maintained by browsers ensures that one site cannot corrupt or steal data from another. However a browser exploit such as cross-site cooking can be used to move things across the logical security boundaries.


Origins

The name cross-site cooking and concept was presented by Michal Zalewski in 2006. The name is a mix of cookie and cross-site, attempting to describe the nature of cookies being set across sites.

In Michal Zalewski’s article of 2006, Benjamin Franz was credited for his discovery, who in May 1998 reported a cookie domain related vulnerability to vendors. Benjamin Franz published the vulnerability and discussed it mainly as a way to circumvent “privacy protection” mechanisms in popular browsers. Michal Zalewski concluded that the bug, 8 years later, was still present (unresolved) in some browsers and could be exploited for cross-site cooking. Various remarks such as “vendors […] certainly are not in a hurry to fix this” was made by Zalewski and others.


External links

  • Cross-Site Cooking article by Michal Zalewski. Details concept, 3 bugs which enables Cross Site Cooking. One of these bugs is the age old bug originally found by Benjamin Franz.

Ketoacidosis. IDDM is - Medicine

Thursday, July 17th, 2008

Medicine is the science and “art” of maintaining and/or restoring human health through the study, diagnosis, and treatment of patients.
The term is derived from the Latin ars medicina meaning the art of healing.Etymology: Latin: medicina, from ars medicina “the medical art,” from medicus “physician.”(Etym.Online)
Cf. mederi “to heal,” etym. “know the best course for,” from PIE base *med- “to measure, limit. Cf. Greek medos “counsel, plan,” Avestan vi-mad “physician”)http://www.etymonline.com/index.php?term=medicine

The modern practice of medicine occurs at the many interfaces between the art of healing and various sciences. Medicine is directly connected to the health sciences and biomedicine. Broadly speaking, the term ‘Medicine’ today refers to the fields of clinical medicine, medical research and surgery, thereby covering the challenges of disease and injury.

Contents


Overview

Since the 19th century, only those with a medical degree have been considered eligible to practice medicine. Clinicians (licensed professionals who deal with patients) can be physicians, physical therapists, physician assistants, nurses or others. The medical profession is the social and occupational structure of the group of people formally trained and authorized to apply medical knowledge. Many countries and legal jurisdictions have legal limitations on who may practice medicine.

Medicine comprises various specialized sub-branches, such as cardiology, pulmonology, neurology, or other fields such as sports medicine, research or public health.

Human societies have had various different systems of health care practice since at least the beginning of recorded history. Medicine, in the modern period, is the mainstream scientific tradition which developed in the Western world since the early Renaissance (around 1450). Many other traditions of health care are still practiced throughout the world; most of these are separate from Western medicine, which is also called biomedicine, allopathic medicine or the Hippocratic tradition. The most highly developed of these are traditional Chinese medicine, Traditional Tibetan medicine and the Ayurvedic traditions of India and Sri Lanka. Various non-mainstream traditions of health care have also developed in the Western world. These systems are sometimes considered companions to Hippocratic medicine, and sometimes are seen as competition to the Western tradition. Few of them have any scientific confirmation of their tenets, because if they did they would be brought into the fold of Western medicine.

“Medicine” is also often used amongst medical professionals as shorthand for internal medicine. Veterinary medicine is the practice of health care in animal species other than human beings.


History of medicine

The earliest type of medicine in most cultures was the use of plants (Herbalism) and animal parts. This was usually in concert with ‘magic’ of various kinds in which: animism (the notion of inanimate objects having spirits); spiritualism (here meaning an appeal to gods or communion with ancestor spirits); shamanism (the vesting of an individual with mystic powers); and divination (the supposed obtaining of truth by magic means), played a major role.

The practice of medicine developed gradually in ancient Egypt, India, China, Greece, Persia, the Islamic world, medieval Europe, and elsewhere. Medicine as it is now practiced largely developed during the 2nd millenium in Spain (Abulcasis, 11th century), Persia (Avicenna, 11th century), Syria (Ibn al-Nafis, 13th century), England (William Harvey, 17th century), Germany (Rudolf Virchow) and France (Jean-Martin Charcot, Claude Bernard and others). The new “scientific” medicine (where results are testable and repeatable) replaced early Western traditions of medicine, based on herbalism, the Greek “four humours” and other pre-modern theories. The focal points of development of clinical medicine shifted to the United Kingdom and the USA by the early 1900s (Canadian-born) Sir William Osler, Harvey Cushing). Possibly the major shift in medical thinking was the gradual rejection in the 1400s during the Black Death of what may be called the ‘traditional authority’ approach to science and medicine. This was the notion that because some prominent person in the past said something must be so, then that was the way it was, and anything one observed to the contrary was an anomaly (which was paralleled by a similar shift in European society in general - see Copernicus’s rejection of Ptolemy’s theories on astronomy). People like Vesalius led the way in improving upon or indeed rejecting the theories of great authorities from the past such as Galen, Hippocrates, and Avicenna/Ibn Sina, all of whose theories were in time almost totally discredited. Such new attitudes were also only made possible by the weakening of the Roman Catholic church’s power in society, especially in the Republic of Venice.

Evidence-based medicine is a recent movement to establish the most effective algorithms of practice (ways of doing things) through the use of the scientific method and modern global information science by collating all the evidence and developing standard protocols which are then disseminated to healthcare providers. One problem with this ‘best practice’ approach is that it could be seen to stifle novel approaches to treatment.

Genomics and knowledge of human genetics is already having some influence on medicine, as the causative genes of most monogenic genetic disorders have now been identified, and the development of techniques in molecular biology and genetics are influencing medical practice and decision-making.

Pharmacology has developed from herbalism and many drugs are still derived from plants (atropine, ephedrine, warfarin, aspirin, digoxin, vinca alkaloids, taxol, hyoscine, etc). The modern era began with Robert Koch’s discoveries around 1880 of the transmission of disease by bacteria, and then the discovery of antibiotics shortly thereafter around 1900. The first of these was arsphenamine / Salvarsan discovered by Paul Ehrlich in 1908 after he observed that bacteria took up toxic dyes that human cells did not. The first major class of antibiotics was the sulfa drugs, derived by French chemists originally from azo dyes. Throughout the twentieth century, major advances in the treatment of infectious diseases were observable in (Western) societies. The medical establishment is now developing drugs targeted towards one particular disease process. Thus drugs are being developed to minimise the side effects of prescribed drugs, to treat cancer, geriatric problems, long-term problems (such as high cholesterol), chronic diseases type 2 diabetes, lifestyle and degenerative diseases such as arthritis and Alzheimer’s disease.


Practice of medicine

The practice of medicine combines both science as the evidence base and art in the application of this medical knowledge in combination with intuition and clinical judgment to determine the treatment plan for each patient.

Central to medicine is the patient-physician relationship established when a person with a health concern seeks a physician’s help; the ‘medical encounter’. Other health professionals similarly establish a relationship with a patient and may perform various interventions, e.g. nurses, radiographers and therapists.

As part of the medical encounter, the healthcare provider needs to:

  • develop a relationship with the patient
  • gather data (medical history, systems enquiry, and physical examination, combined with laboratory or imaging studies (investigations))
  • analyze and synthesize that data (assessment and/or differential diagnoses), and then:
  • develop a treatment plan (further testing, therapy, watchful observation, referral and follow-up)
  • treat the patient accordingly
  • assess the progress of treatment and alter the plan as necessary (management).

The medical encounter is documented in a medical record, which is a legal document in many jurisdictions.


Health care delivery systems

Medicine is practiced within the medical system, which is a legal, credentialing and financing framework, established by a particular culture or government. The characteristics of a health care system have significant effect on the way medical care is delivered.

Financing has a great influence as it defines who pays the costs. Aside from tribal cultures, the most significant divide in developed countries is between universal health care and market-based health care (such as practiced in the U.S.). Universal health care might allow or ban a parallel private market. The latter is described as single-payer system.

Transparency of information is another factor defining a delivery system. Access to information on conditions, treatments, quality and pricing greatly affects the choice by patients / consumers and therefore the incentives of medical professionals. While US health care system has come under fire for lack of openness, new legislation may encourage greater openness. There is a perceived tension between the need for transparency on the one hand and such issues as patient confidentiality and the possible exploitation of information for commercial gain on the other.


Health care delivery

Medical care delivery is classified into primary, secondary and tertiary care.

Primary care medical services are provided by physicians or other health professionals who have first contact with a patient seeking medical treatment or care. These occur in physician offices, clinics, nursing homes, schools, home visits and other places close to patients. About 90% of medical visits can be treated by the primary care provider. These include treatment of acute and chronic illnesses, preventive care and health education for all ages and both sexes.

Secondary care medical services are provided by medical specialists in their offices or clinics or at local community hospitals for a patient referred by a primary care provider who first diagnosed or treated the patient. Referrals are made for those patients who required the expertise or procedures performed by specialists. These include both ambulatory care and inpatient services, emergency rooms, intensive care medicine, surgery services, physical therapy, labor and delivery, endoscopy units, diagnostic laboratory and medical imaging services, hospice centers, etc. Some primary care providers may also take care of hospitalized patients and deliver babies in a secondary care setting.

Tertiary care medical services are provided by specialist hospitals or regional centers equipped with diagnostic and treatment facilities not generally available at local hospitals. These include trauma centers, burn treatment centers, advanced neonatology unit services, organ transplants, high-risk pregnancy, radiation oncology, etc.

Modern medical care also depends on information - still delivered in many health care settings on paper records, but increasingly nowadays by electronic means.


Patient-physician-relationship

This kind of relationship and interaction is a central process in the practice of medicine. There are many perspectives from which to understand and describe it.

An idealized physician’s perspective, such as is taught in medical school, sees the core aspects of the process as the physician learning the patient’s symptoms, concerns and values; in response the physician examines the patient, interprets the symptoms, and formulates a diagnosis to explain the symptoms and their cause to the patient and to propose a treatment. The job of a physician is similar to a human biologist: that is, to know the human frame and situation in terms of normality. Once the physician knows what is normal and can measure the patient against those norms, he or she can then determine the particular departure from the normal and the degree of departure. This is called the diagnosis.

The four great cornerstones of diagnostic medicine are anatomy (structure: what is there), physiology (how the structure/s work), pathology (what goes wrong with the anatomy and physiology) and psychology (mind and behavior). In addition, the physician should consider the patient in their ‘well’ context rather than simply as a walking medical condition. This means the socio-political context of the patient (family, work, stress, beliefs) should be assessed as it often offers vital clues to the patient’s condition and further management. In more detail, the patient presents a set of complaints (the symptoms) to the physician, who then obtains further information about the patient’s symptoms, previous state of health, living conditions, and so forth. The physician then makes a review of systems (ROS) or systems inquiry, which is a set of ordered questions about each major body system in order: general (such as weight loss), endocrine, cardio-respiratory, etc. Next comes the actual physical examination; the findings are recorded, leading to a list of possible diagnoses. These will be in order of probability. The next task is to enlist the patient’s agreement to a management plan, which will include treatment as well as plans for follow-up. Importantly, during this process the healthcare provider educates the patient about the causes, progression, outcomes, and possible treatments of his ailments, as well as often providing advice for maintaining health. This teaching relationship is the basis of calling the physician doctor, which originally meant “teacher” in Latin. The patient-physician relationship is additionally complicated by the patient’s suffering (patient derives from the Latin patior, “suffer”) and limited ability to relieve it on his/her own. The physician’s expertise comes from his knowledge of what is healthy and normal contrasted with knowledge and experience of other people who have suffered similar symptoms (unhealthy and abnormal), and the proven ability to relieve it with medicines (pharmacology) or other therapies about which the patient may initially have little knowledge.

The physician-patient relationship can be analyzed from the perspective of ethical concerns, in terms of how well the goals of non-maleficence, beneficence, autonomy, and justice are achieved. Many other values and ethical issues can be added to these. In different societies, periods, and cultures, different values may be assigned different priorities. For example, in the last 30 years medical care in the Western World has increasingly emphasized patient autonomy in decision making.

The relationship and process can also be analyzed in terms of social power relationships (e.g., by Michel Foucault), or economic transactions. Physicians have been accorded gradually higher status and respect over the last century, and they have been entrusted with control of access to prescription medicines as a public health measure. This represents a concentration of power and carries both advantages and disadvantages to particular kinds of patients with particular kinds of conditions. A further twist has occurred in the last 25 years as costs of medical care have risen, and a third party (an insurance company or government agency) now often insists upon a share of decision-making power for a variety of reasons, reducing freedom of choice of healthcare providers and patients in many ways.

The quality of the patient-physician relationship is important to both parties. The better the relationship in terms of mutual respect, knowledge, trust, shared values and perspectives about disease and life, and time available, the better will be the amount and quality of information about the patient’s disease transferred in both directions, enhancing accuracy of diagnosis and increasing the patient’s knowledge about the disease. Where such a relationship is poor the physician’s ability to make a full assessment is compromised and the patient is more likely to distrust the diagnosis and proposed treatment. In these circumstances and also in cases where there is genuine divergence of medical opinions, a second opinion from another physician may be sought.

In some settings, e.g. the hospital ward, the patient-physician relationship is much more complex, and many other people are involved when somebody is ill: relatives, neighbors, rescue specialists, nurses, technical personnel, social workers and others.


Clinical skills

A complete medical evaluation includes a medical history, a systems enquiry, a physical examination, appropriate laboratory or imaging studies, analysis of data and medical decision making to obtain diagnoses, and a treatment plan.

The components of the medical history are:

  • Chief complaint (CC): the reason for the current medical visit. These are the ’symptoms.’ They are in the patient’s own words and are recorded along with the duration of each one. Also called ‘presenting complaint.’
  • History of present illness / complaint (HPI): the chronological order of events of symptoms and further clarification of each symptom.
  • Current activity: occupation, hobbies, what the patient actually does.
  • Medications (DHx): what drugs the patient takes including prescribed, over-the-counter, and home remedies, as well as alternative and herbal medicines/herbal remedies such as St John’s wort. Allergies are also recorded.
  • Past medical history (PMH/PMHx): concurrent medical problems, past hospitalizations and operations, injuries, past infectious diseases and/or vaccinations, history of known allergies.
  • Social history (SH): birthplace, residences, marital history, social and economic status, habits (including diet, medications, tobacco, alcohol).
  • Family history (FH): listing of diseases in the family that may impact the patient. A family tree is sometimes used.
  • Review of systems (ROS) or systems inquiry: a set of additional questions to ask which may be missed on HPI: a general enquiry (have you noticed any weight loss, fevers, lumps and bumps? etc), followed by questions on the body’s main organ systems (heart, lungs, digestive tract, urinary tract, etc).

The physical examination is the examination of the patient looking for signs of disease (’Symptoms’ are what the patient volunteers, ‘Signs’ are what the healthcare provider detects by examination). The healthcare provider uses the senses of sight, hearing, touch, and sometimes smell (taste has been made redundant by the availability of modern lab tests). Four chief methods are used: inspection, palpation (feel), percussion (tap to determine resonance characteristics), and auscultation (listen); smelling may be useful (e.g. infection, uremia, diabetic ketoacidosis). The clinical examination involves study of:

  • Vital signs including height, weight, body temperature, blood pressure, pulse, respiration rate, hemoglobin oxygen saturation
  • General appearance of the patient and specific indicators of disease (nutritional status, presence of jaundice, pallor or clubbing)
  • Skin
  • Head, eye, ear, nose, and throat (HEENT)
  • Cardiovascular (heart and blood vessels)
  • Respiratory (large airways and lungs)
  • Abdomen and rectum
  • Genitalia (and pregnancy if the patient is or could be pregnant)
  • Musculoskeletal (spine and extremities)
  • Neurological (consciousness, awareness, brain, cranial nerves, spinal cord and peripheral nerves)
  • Psychiatric (orientation, mental state, evidence of abnormal perception or thought)

Laboratory and imaging studies results may be obtained, if necessary.

The medical decision-making (MDM) process involves analysis and synthesis of all the above data to come up with a list of possible diagnoses (the differential diagnoses), along with an idea of what needs to be done to obtain a definitive diagnosis that would explain the patient’s problem.

The treatment plan may include ordering additional laboratory tests and studies, starting therapy, referral to a specialist, or watchful observation. Follow-up may be advised.

This process is used by primary care providers as well as specialists. It may take only a few minutes if the problem is simple and straightforward. On the other hand, it may take weeks in a patient who has been hospitalized with bizarre symptoms or multi-system problems, with involvement by several specialists.

On subsequent visits, the process may be repeated in an abbreviated manner to obtain any new history, symptoms, physical findings, and lab or imaging results or specialist consultations.


Branches of medicine

Working together as an interdisciplinary team, many highly trained health profession also besides medical practitioners are involved in the delivery of modern health care. Some examples include: nurse(s) emergency medical technicians and paramedics, laboratory scientists, (pharmacy, pharmacists), (physiotherapy,physiotherapists), respiratory therapists, speech therapists, occupational therapists, radiographers, dietitians and bioengineers.

The scope and sciences underpinning human medicine overlap many other fields. Dentistry and psychology, while separate disciplines from medicine, are considered medical fields.

Midlevel Practitioners
Nurse practitioners, midwives and physician assistants, treat patients and prescribe medication in many legal jurisdictions.
Veterinary Medicine
Veterinarians apply similar techniques as physicians to the care of animals. The original focus of veterinary medicine was primarily the health care of domestic animals. In recent years the discipline has broadened to include all vertebrate animals and even some of the more economically valuable or scientifically interesting invertebrates. Veterinary and human medicine had similar origins but diverged in the West largely under the influence of Christian doctrine which emphasized a fundamental difference between humans and all other species. The two disciplines re-converged to some degree after the Renaissance when scientific study of anatomy and physiology revealed undeniable similarities between humans and other animals. The similarities further extend into pathology and disease control leading the early pioneer in scientific pathology Rudolph Virchow to proclaim the doctrine of “one medicine.”

Physicians have many specializations and subspecializations which are listed below. There are variations from country to country regarding which specialties certain subspecialities are in.


Diagnostic specialties

  • Clinical laboratory sciences are the clinical diagnostic services which apply laboratory techniques to diagnosis and management of patients. In the United States these services are supervised by a pathologist. The personnel that work in these medical laboratory departments are technically trained staff, each of whom usually hold a medical technology degree, who actually perform the tests, assays, and procedures needed for providing the specific services.
  • Pathology is the branch of medicine that deals with the study of diseases and the morphologic, physiologic changes produced by them. As a diagnostic specialty, pathology can be considered the basis of modern scientific medical knowledge and plays a large role in evidence-based medicine. Many modern molecular tests such as flow cytometry, polymerase chain reaction (PCR), immunohistochemistry, cytogenetics, gene rearragements studies and fluorescent in situ hybridization (FISH) fall within the territory of pathology.
  • Radiology is concerned with imaging of the human body, e.g. by x-rays, x-ray computed tomography, ultrasonography, and nuclear magnetic resonance tomography.


Clinical disciplines

  • Anesthesiology (AE) or anaesthesia (BE) is the clinical discipline concerned with providing anesthesia. Pain medicine is often practiced by specialised anesthesiologists/anesthetists.
  • Dermatology is concerned with the skin and its diseases. In the UK, dermatology is a subspeciality of general medicine.
  • Emergency medicine is concerned with the diagnosis and treatment of acute or life-threatening conditions, including trauma, surgical, medical, pediatric, and psychiatric emergencies.
  • Gender-based medicine studies the biological and physiological differences between the human sexes and how that affects differences in disease.
  • General practice, family practice, family medicine or primary care is, in many countries, the first port-of-call for patients with non-emergency medical problems. Family practitioners are usually able to treat over 90% of all complaints without referring to specialists.
  • Geriatrics focuses on health promotion and the prevention and treatment of disease and disability in later life.
  • Hospital medicine is the general medical care of hospitalized patients. Physicians whose primary professional focus is hospital medicine are called hospitalists in the USA.
  • Internal medicine is concerned with systemic diseases of adults, i.e. those diseases that affect the body as a whole (restrictive, current meaning), or with all adult non-operative somatic medicine (traditional, inclusive meaning), thus excluding pediatrics, surgery, gynaecology and obstetrics, and psychiatry. There are several subdisciplines of internal medicine:
    • Cardiology
    • Critical Care
    • Endocrinology
    • Gastroenterology
    • Hematology
    • Infectious Diseases
    • Intensive care medicine
    • Nephrology
    • Oncology
    • Pulmonology
    • Rheumatology
    • Urology
  • Neurology is concerned with the diagnosis and treatment of nervous system diseases. It is a subspeciality of general medicine in the UK.
  • Obstetrics and gynaecology (often abbreviated as Ob/Gyn) are concerned respectively with childbirth and the female reproductive and associated organs. Reproductive medicine and fertility medicine are generally practiced by gynecological specialists.
  • Palliative care is a relatively modern branch of clinical medicine that deals with pain and symptom relief and emotional support in patients with terminal illnesses including cancer and heart failure.
  • Pediatrics (AE) or paediatrics (BE) is devoted to the care of infants, children, and adolescents. Like internal medicine, there are many pediatric subspecialities for specific age ranges, organ systems, disease classes, and sites of care delivery. Most subspecialities of adult medicine have a pediatric equivalent such as pediatric cardiology, pediatric endocrinology, pediatric gastroenterology, pediatric hematology, pediatric oncology, pediatric ophthalmology, and neonatology.
  • Physical medicine and rehabilitation (or physiatry) is concerned with functional improvement after injury, illness, or congenital disorders.
  • Preventive medicine is the branch of medicine concerned with preventing disease.
  • Psychiatry is the branch of medicine concerned with the bio-psycho-social study of the etiology, diagnosis, treatment and prevention of cognitive, perceptual, emotional and behavioral disorders. Related non-medical fields include psychotherapy and clinical psychology.
  • Radiation therapy is concerned with the therapeutic use of ionizing radiation and high energy elementary particle beams in patient treatment.
  • Radiology is concerned with the interpretation of imaging modalities including x-rays, ultrasound, radioisotopes, and MRI (Magnetic Resonance Imaging). A newer branch of radiology, interventional radiology, is concerned with using medical devices to access areas of the body with minimally invasive techniques.
  • Surgical specialties employ operative treatment. These include Orthopedics, Urology, Ophthalmology, Neurosurgery, Plastic Surgery, Otolaryngology and various subspecialties such as transplant and cardiothoracic. Some disciplines are highly specialized and are often not considered subdisciplines of surgery, although their naming might suggest so.
  • Urgent care focuses on delivery of unscheduled, walk-in care outside of the hospital emergency department for injuries and illnesses that are not severe enough to require care in an emergency department.


Interdisciplinary fields

Interdisciplinary sub-specialties of medicine are:

  • Aerospace medicine deals with medical problems related to flying and space travel.
  • Bioethics is a field of study which concerns the relationship between biology, science, medicine and ethics, philosophy and theology.
  • Biomedical Engineering is a field dealing with the application of engineering principles to medical practice.
  • Clinical pharmacology is concerned with how systems of therapeutics interact with patients.
  • Conservation medicine studies the relationship between human and animal health, and environmental conditions. Also known as ecological medicine, environmental medicine, or medical geology.
  • Disaster medicine deals with medical aspects of emergency preparedness, disaster mitigation and management.
  • Diving medicine (or hyperbaric medicine) is the prevention and treatment of diving-related problems.
  • Evolutionary medicine is a perspective on medicine derived through applying evolutionary theory.
  • Forensic medicine deals with medical questions in legal context, such as determination of the time and cause of death.
  • Keraunomedicine is the medical study of lightning casualties.
  • Medical humanities includes the humanities (literature, philosophy, ethics, history and religion), social science (anthropology, cultural studies, psychology, sociology), and the arts (literature, theater, film, and visual arts) and their application to medical education and practice.
  • Medical informatics, medical computer science, medical information and eHealth are relatively recent fields that deal with the application of computers and information technology to medicine.
  • Naturopathic medicine is concerned with primary care, natural remedies, patient education and disease prevention.
  • Nosology is the classification of diseases for various purposes.
  • Occupational Medicine deals with medical problems related to work and the working environment.
  • Osteopathic medicine claims that much disease results from problems with bones and joints.
  • Pharmacogenomics is a form of individualized medicine.
  • Sports medicine deals with the treatment and preventive care of athletes, amateur and professional. The team includes specialty physicians and surgeons, athletic trainers, physical therapists, coaches, other personnel, and, of course, the athlete.
  • Therapeutics is the field, more commonly referenced in earlier periods of history, of the various remedies that can be used to treat disease and promote health [1].
  • Travel medicine or emporiatrics deals with health problems of international travelers or travelers across highly different environments.


Medical education

Medical education is education connected to the practice of being a medical practitioner, either the initial training to become a physician or further training thereafter.

Medical education and training varies considerably across the world, however typically involves entry level education at a university medical school, followed by a period of supervised practice (Internship and/or Residency) and possibly postgraduate vocational training. Continuing medical education is a requirement of many regulatory authorities.

Various teaching methodologies have been utilised in medical education, which is an active area of educational research.

Presently, in England, a typical medicine course at university is 5 years (4 if the student already holds a degree). Amongst some institutions and for some students, it may be 6 years (including the selection of an intercalated BSc - taking one year - at some point after the pre-clinical studies). This is followed by 2 Foundation years afterwards, namely F1 and F2. Students register with the UK General Medical Council at the end of F1. At the end of F2, they may pursue further years of study.

In the USA, a potential medical student must first complete an undergraduate degree (Typically a BSc with a major in biology, biochemistry or medical science), before applying to a graduate medical school to pursue the M.D.

In Australia, students have two options. They can choose to take a six-year undergraduate Bachelor of Medicine/Bachelor of Surgery (MBBS) straight from high school, or complete a undergraduate degree and then a four year Bachelor of Medicine/Bachelor of Surgery (BMBS) program.


Legal restrictions

In most countries, it is a legal requirement for medical doctors to be licensed or registered. In general, this entails a medical degree from a university and accreditation by a medical board or an equivalent national organization, which may ask the applicant to pass exams. This restricts the considerable legal authority of the medical profession to physicians that are trained and qualified by national standards. It is also intended as an assurance to patients and as a safeguard against charlatans that practice inadequate medicine for personal gain. While the laws generally require medical doctors to be trained in “evidence based”, Western, or Hippocratic Medicine, they are not intended to discourage different paradigms of health.


Criticism

Criticism of medicine has a long history. In the Middle Ages, some people did not consider it a profession suitable for Christians, as disease was often considered God-sent. God was considered to be the ‘divine physician’ who sent illness or healing depending on his will. However, many monastic orders, particularly the Benedictines, considered the care of the sick as their chief work of mercy. Barber-surgeons generally had a bad reputation that was not to improve until the development of academic surgery as a speciality of medicine, rather than an accessory field.

Through the course of the twentieth century, healthcare providers focused increasingly on the technology that was enabling them to make dramatic improvements in patients’ health. The ensuing development of a more mechanistic, detached practice, with the perception of an attendant loss of patient-focused care, known as the medical model of health, led to further criticisms. This issue started to reach collective professional consciousness in the 1970s and the profession had begun to respond by the 1980s and 1990s.

The noted anarchist Ivan Illich heavily criticized modern medicine. In his 1976 work Medical Nemesis, Illich stated that modern medicine only medicalises disease and causes loss of health and wellness, while generally failing to restore health by eliminating disease. This medicalisation of disease forces the human to become a lifelong patient. Other less radical philosophers have voiced similar views, but none were as virulent as Illich. Another example can be found in Technopoly: The Surrender of Culture to Technology by Neil Postman, 1992, which criticises overreliance on technological means in medicine.

Criticism of modern medicine has led to some improvements in the curricula of medical schools, which now teach students systematically on medical ethics, holistic approaches to medicine, the biopsychosocial model and similar concepts.

The inability of modern medicine to properly address some common complaints continues to prompt many people to seek support from alternative medicine. Although most alternative approaches lack scientific validation, some may be effective in individual cases. Some physicians combine alternative medicine with orthodox approaches.

Medical errors and overmedication are also the focus of many complaints and negative coverage. Practitioners of human factors engineering believe that there is much that medicine may usefully gain by emulating concepts in aviation safety, where it was long ago realized that it is dangerous to place too much responsibility on one “superhuman” individual and expect him or her not to make errors. Reporting systems and checking mechanisms are becoming more common in identifying sources of error and improving practice.


See also

  • Alternative medicine
  • Big killers
  • Bioethics
  • Branches of medicine
  • Diagnosis
  • Health
  • Health care
  • Health profession
  • Health care system
  • Iatrogenesis
  • Life extension
  • List of diseases
  • List of disorders
  • List of medical abbreviations
  • List of medical roots
  • List of medical schools
  • Important publications in medicine
  • Medical dictionary
  • Medical equipment
  • Medical ethics
  • Medical literature
  • Medicalization
  • Naturopathic Medicine
  • Pandemic
  • Patient
  • Pharmaceutical company
  • Physician
  • Rare diseases
  • Surgery
  • Traumatology


References


External links

  • NLM (US National Library of Medicine, contains resources for patients and health care professionals)
  • eMedicine Physician contributed medical articles and CME
  • WebMD General comprehensive online health information
  • KMLE Medical Dictionary Medical dictionary and medical related links

Americans - Joseph Orono

Saturday, July 12th, 2008

Joseph Orono was a Penobscot Indian chief who helped the Americans during the Revolution.

When the Revolutionary War broke out General George Washington requested the assistance of the Wabanaki People. In 1775, a British warship destroyed Fort Pownall, which the Penobscots had used for trade. The Penobscots received a letter from the Provincial Congress of Massachusetts urging them to join with the American colonies to defend the liberty of both parties. Joseph Orono urged his fellow Penobscots to side with the Americans.

Chief Orono was from the county of Penobscot in the present day state of Maine, in which a town was named after him - Orono.